杨题隆-爱情岛论坛

杨题隆

职称：副教授

杨题隆，爱情岛论坛 "百人计划"副教授，博士生导师，课题组负责人。2022年获香港科技大学博士学位，2025年2月加入爱情岛论坛。主要从事理论与计算化学研究，具体研究方向包括：有机、无机及金属有机体系的结构与成键分析；计算化学在化学理论发展，反应机理探究，催化剂设计和合成方法学发展等方面的应用。迄今共发表SCI论文46篇，其中第一/通讯作者论文19篇，包括Nat. Chem.（2篇）、Nat. Catal.（1篇）、J. Am. Chem. Soc.（3篇）、Angew. Chem. Int. Ed.（1篇）。H–index为18。

学习与工作经历：

2025.02 –至今爱情岛论坛 “百人计划”副教授

2022.09 – 2025.01 香港科技大学，博士后，合作导师：林振阳教授

2018.08 – 2022.08 香港科技大学，化学博士，导师：林振阳教授

2014.07 – 2018.08 南方科技大学，科研助理，合作导师：党丽教授，张绪穆教授

2011.08 – 2014.03 浙江大学，生物物理学硕士，导师：丁兴成副教授

2007.09 – 2011.07 济南大学，环境工程学士

^‡equal contribution; * corresponding author

[46] Mechanistic insights into copper-catalyzed asymmetric cyanation of allylic C–H bonds

J. Li,^‡ T. Yang,^‡ P. Chen, F. Shiri, H. Guan*, Z. Lin* and G. Liu*, J. Am. Chem. Soc., 147, 14756–14768, 2025.

[45] Site- and enantioselective allylic and propargylic C–H oxidation enabled by copper-based biomimetic catalysis

H. Zhang,^‡ Y. Zhou,^‡ T. Yang,^‡ J. Wu, P. Chen, Z. Lin* and G. Liu*, Nat. Catal. 8, 58–66, 2025.

71702

[44] Cobalt-catalyzed desymmetrization of malononitriles via enantioselective borohydride reduction

Y. Zheng,^‡ T. Yang,^‡ K. F. Chan, Z. Lin* and Z. Huang*, Nat. Chem., 16, 1845–1854 , 2024.

[43] Regio- and enantioselective remote dioxygenation of internal alkenes

X. Li,^‡ T. Yang,^‡ J. Li, X. Li, P. Chen, Z. Lin* and G. Liu*, Nat. Chem., 15, 862–871, 2023.

[42] Iridium-catalyzed enantioselective hydrogenation of oxocarbenium ions: a case of ionic hydrogenation

T. Yang,^‡ Y. Sun,^‡ H. Wang, Z. Lin*, J. Wen* and X. Zhang, Angew. Chem. Int. Ed., 59, 6108–6114, 2020.

[41] Site-selective sp² C-H cyanation of allenes via copper-catalyzed radical relay

Z. Cheng,^‡ T. Yang,^‡ C. Li,^‡ Y. Deng, F. Zhang, P. Chen, Z. Lin*, S. Ma* and G. Liu*, J. Am. Chem. Soc., 145, 225995–26002, 2023.

[40] Enantioselective copper-catalyzed radical cyanation of propargylic C–H bonds: easy access to chiral allenyl nitriles

R. Lu,^‡ T. Yang,^‡ X. Chen, W. Fan, P. Chen, Z. Lin* and G. Liu*, J. Am. Chem. Soc., 143, 14451–14457, 2021.

[39] W. Li,^‡ T. Yang,^‡ N. Song, R. Li, J. Long, H. Lin, X. Zhang, and H. Lv*, Ir/f-ampha complex catalyzed asymmetric sequential hydrogenation of enones: a general access to chiral alcohols with two contiguous chiral centers, Chem. Sci., 13, 1808–1814, 2022.

[38] Y. Li,^‡ Y. Wang,^‡ T. Yang,^‡ Z. Lin* and X. Jiang*, Selenium-catalyzed intramolecular atom- and redox-economical transformation of o-nitrotoluenes into anthranilic acids, Green Chem., 23, 2986–2991, 2021.

[37] X. Du,Y. Zhang, T. Yang,* Y. Xiao, J. He, L. W. Chung, G-Q. Chen* and X. Zhang*, A versatile cobalt catalyst for highly enantioselective hydrogenation of carbonyl compounds, Chem Catal., 4, 100999, 2024.

[36] W. H. M. Wong, X. Guo, H. T. Chan, T. Yang* and Z. Lin*, Understanding the organometallic step: SO₂ insertion into Bi(III)-C(Ph) bond, Chem. Asian J. 18, e202201218, 2023. (Mechanisms and selectivities of organic reactions to celebrate Professor Houk's 80th birthday).

[35] T. Yang, S. Ni, P. Qin and L. Dang*, A mechanism study on the hydrogen evolution reaction catalyzed by molybdenum disulfide complexes, Chem. Commun., 54, 1113–1116, 2018.

[34] T. Yang, H. T. Chan, W. H. M. Wong, K. L. Chan, F. K. Sheong* and Z. Lin*, Cobalt(I) pincer complexes: four– versus five–coordination, Eur. J. Inorg. Chem., e202200267, 2022 (Institute feature: Hong Kong universities).

[33] T. Yang, F. K. Sheong* and Z. Lin*, Understanding of Co(I)-catalyzed hydrogenation of C=C and C=O substrates, Top Catal, 65, 472–480, 2022 (Computational catalysis: a land of opportunities).

[32] T. Yang, S. Ni, P. Zhang and L. Dang*, Ligand effect on the reactivity difference of Mo tris(dithiolene) complexes towards ethylene: a computational study, J. Organomet. Chem., 806, 60–67, 2016.

[31] K–F. Lee,^‡ T. Yang,^‡ L–Y. Tsang, H. H. Y. Sung, I. D. Williams*, Z. Lin* and G. Jia*, Azavinylidene complexes from coupling reactions of organonitriles with phosphines, Organometallics, 40, 358–369, 2021.

[30] W. Ruan,^‡ T. Yang,^‡ C. Shi, W. Bai, H. H. Y. Sung, I. D. Williams*, Z. Lin* and G. Jia*, Substituent effect on the reactions of OsCl₂(PPh₃)₃ with o–ethynylphenyl carbonyl compounds, Organometallics, 39, 574–584, 2020.

[29] L. Yang, T. Yang, Y. Qian, X. Zhang* and J. Wen*, Desymmetric Hydrogenation of meso-Dicarboxylic Acids, J. Am. Chem. Soc., 146, 15908–15916, 2024.

[28] F. Wang, T. Yang, T. Wu, L–S. Zheng, C. Yin, Y. Shi, X–Y. Ye, G–Q. Chen* and X. Zhang*, Asymmetric transfer hydrogenation of α-substituted-β-keto carbonitriles via dynamic kinetic resolution, J. Am. Chem. Soc., 143, 2477–2483, 2021.

[27] N–Y. Duan, X. Du, Z. Cui, Y. Zeng, Y. Liu, T. Yang, J. Wen* and X. Zhang*, Homogeneous hydrogenation with a cobalt/tetraphosphine catalyst: a superior hydride donor for polar double bonds and N–heteroarenes, J. Am. Chem. Soc., 141, 20424–20433, 2020.

[26] L. Xu, T. Yang, H. Sun, J. Zeng, S. Mu, J. Qiu, X. Zhang and G–Q. Chen*, Rhodium-catalyzed asymmetric hydrogenation and transfer hydrogenation of 1,3-dipolar nitrones, Angew. Chem. Int. Ed., e202319662, 2024.

[25] B. Lin, T. Yang, D. Zhang, Y. Zhou, L. Wu, J. Qiu, G–Q. Chen*, C–M. Che* and X. Zhang*, Gold-catalyzed desymmetric lactonization of alkynylmalonic acids enabled by chiral bifunctional P,N ligands, Angew. Chem. Int. Ed., 61, e202201739, 2022.

[24] L–L. Wang, M. Quan, T. Yang, Z. Chen, and W. Jiang*, A green and wide-scope approach for chiroptical sensing of organic molecules through biomimetic recognition in water, Angew. Chem. Int. Ed., 59, 23817–23824, 2020.

[23] J. Zheng, R. Fan, H. Wu, H. Yao, Y. Yan, J. Liu, L. Ran, Z. Sun, L. Yi, L. Dang, P. Gan, P. Zheng, T. Yang, Y. Zhang*, T. Tang* and Y. Wang*, Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation, Nat. Commun., 10, 1604, 2019.

[22] B.Lin, Y. Xiao, T. Yang, G-Q. Chen*, Xumu Zhang*, Chi-Ming Che*, Gold-catalyzed highly enantioselective cycloadditions of 1,6-enynes and 1,6-diynes assisted by remote hydrogen bonding interaction, iscience, 27, 110876, 2024.

[21] Y. Ren*, T. Yang and Z. Lin*, Insights into mechanism and selectivity in Rh(I)-catalyzed cycloisomerization reaction of benzylallene-alkynes involving C−H bond activation, Org. Chem. Front., 10, 115–126, 2023.

[20] J. Jiao, H. He, T. Yang, T. Zhang, L. Wang, T. Han, Y. Nie*, Z. Lin* and P. Li*, Asymmetric synthesis of metallacarboranes using a traceless chiral auxiliary, Org. Chem. Front., 10, 5965–5970, 2023.

[19] G. Gu, T. Yang, J. Lu, J. Wen, L. Dang*, X, Zhang*, Iridium/f–ampha–catalyzed asymmetric hydrogenation of aromatic α-keto esters, Org. Chem. Front., 5, 1209–1212, 2018.

[18] X. Guo, T. Yang, F. K. Sheong* and Z. Lin*, Beyond the nucleophilic role of metal-boryl complexes in borylation reactions, ACS Catal., 11, 5061–5068, 2021.

[17] J. Li, J. Zhou, Y. Wang, Y. Yu, Q. Liu, T. Yang, H. Chen* and H. Cao*, Mechanistic insight into the synergistic Cu/Pd-catalyzed carbonylation of aryl iodides using alcohols and dioxygen as the carbonyl source, Sci. China Chem., 65, 68–74, 2022.

[16] Sun, Q. Zhao, H. Wang, T. Yang, J. Wen* and X. Zhang*, Asymmetric hydrogenation of cationic intermediates for the synthesis of chiral N,O–acetals, Chem. Eur. J., 26, 11470–11477, 2020.

[15] L–L. Wang, H. Zhou, T. Yang, H. Ke, Y–K. Tu, H. Yao and W. Jiang*, Bis–naphthalene cleft with aggregation-induced emission properties through lone-pair⋅⋅⋅π Interactions, Chem. Eur. J., 24, 16757–16761, 2018.

[14] X. Guo, T. Yang, Y. C. Zhang, F. K. Sheong* and Z. Lin*, Reactivity of unsupported transition metal-aluminyl complexes: a nucleophilic TM-Al Bond, Inorg. Chem., 61, 10255–10262, 2022.

[13] X. Lin, P. Qin, S. Ni, T. Yang, M. Li and L. Dang*, Priority of mixed diamine ligands in cobalt dithiolene complex-catalyzed H₂ evolution: a theoretical study, Inorg. Chem., 60, 6688–6695, 2021.

[12] H. Wang, Y. Zhang, T. Yang, X. Guo, Q. Gong, J. Wen* and X. Zhang*, Chiral electron–rich PNP ligand with a phospholane motif: structural features and application in asymmetric hydrogenation, Org. Lett., 22, 8796–8801, 2020.

[11] G. Gu, T. Yang, O. Yu, H. Qian, J. Wang, J. Wen, L. Dang* and X. Zhang*, Enantioselective iridium–catalyzed hydrogenation of α–keto amides to α–hydroxy amides, Org. Lett., 19, 5920–5923, 2017.

[10] F. Jia, D. Li, T. Yang, L. Yang, L. Dang, W, Jiang*, Oxatub[5,6]arene: synthesis, conformation analysis and recognition of C60 and C70, Chem. Commun., 53, 336–339, 2017.

[9] X. Guo, T. Yang and Z. Lin*, Understanding the diverse reactivity of pentaphenylborole toward epoxides, J. Org. Chem., 85, 14139–14148, 2020.

[8] Z. Liang, T. Yang, G. Gu, L. Dang* and X. Zhang*, Scope and mechanism on iridium–f–amphamide catalyzed asymmetric hydrogenation of ketones, Chin. J. Chem., 36, 851–856, 2018.

[7] Z. Zhang, T. Yang, P. Qin and L. Dang*, Nickel bis(dithiolene) complexes for electrocatalytic hydrogen evolution: a computational study. J. Organomet. Chem., 864, 143–147, 2018.

[6] S. Ni, T. Yang and L. Dang*, Transfer hydrocyanation by the nickel(0)/Lewis acid cooperative catalysis, mechanism investigation and computational prediction of shuttle catalysts, Organometallics, 36, 2746–2754, 2017.

[5] M. Zhou, T. Yang and L. Dang*, Theoretical studies on palladium–mediated enantioselective C–H iodination, J. Org. Chem., 81, 1006-1020, 2016.

Works in Environmental Science

[4] T. Yang, Y. Chen, Z. Wang, Q. Ye, and H. Wang*, Fate characterization of bound residues of ¹⁴C–Pyraoxystrobin in soils, Chemosphere, 263, 128023, 2021.

[3] T. Yang, C. Xu, X. Liu, X. Chen, J. Zhang, X. Ding*, Fate of a novel strobilurin fungicide pyraoxystrobin in flooded soil, Environ. Sci.: Processes Impacts, 16, 1495–1500, 2014.

[2] C. Xu, J. Wang, T Yang, X. Chen, X. Liu and X. Ding*, Adsorption of uranium by amidoximated chitosan–grafted polyacrylonitrile, using response surface methodology, Carbohydr. Chem., 121, 79–85, 2015.

[1] X. Liu, X. Chen, H. Wang, T Yang, Q. Ye* and X. Ding*, Dynamic characteristics of the novel strobilurin fungicide SYP–3343 in soils, J. Agric. Food Chem., 62, 3343–3347, 2014.